Cardinals vs. Browns odds, line, spread: 2021 NFL picks, Week 6 predictions from proven computer model

The Arizona Cardinals will take on the Cleveland Browns at 4:05 p.m. ET on Sunday at FirstEnergy Stadium. Cleveland is 3-2 overall and 2-0 at home, while the Cardinals are 5-0 overall and 3-0 on the road. The Cardinals beat the 49ers last week, 17-10. The Browns lost to the Chargers, 47-42. 

The Cardinals are the only remaining undefeated team in the NFL. Cleveland is favored by 3.5 points in the latest Browns vs. Cardinals odds from Caesars Sportsbook, and the over-under is set at 48.5. Before entering any Cardinals vs. Browns picks, you’ll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is WAY up.

Now, the model has set its sights on Browns vs. Cardinals. You can head to SportsLine to see its picks. Here are several NFL betting lines for Cardinals vs. Browns:

  • Browns vs. Cardinals spread: Browns -3.5
  • Browns vs. Cardinals over-under: 48.5 points

Featured Game | Cleveland Browns vs. Arizona Cardinals

What you need to know about the Browns

The Browns squandered a 14-point third quarter lead in their Week 5 loss to the Chargers. They allowed 26 points in the fourth quarter. Cleveland rolled up a season-high 531 yards in the defeat. The Browns had 230 rushing yards, but are heading into Week 6 with notable injuries at running back. 

Nick Chubb rushed for 161 yards on 21 carries, including a 52-yard TD. He has been ruled out for the game against Arizona because of a calf injury. Kareem Hunt had two rushing TDs and 61 yards on 12 carries. He is listed as questionable with wrist and knee injuries. Myles Garrett leads the NFL with seven sacks heading into Week 6. 

What you need to know about the Cardinals

The Cardinals have started 5-0 for the first time since the 1974 season. DeAndre Hopkins‘ 9-yard TD catch with 5:13 left gave Arizona a 17-7 lead on its way to the victory. The Cardinals stopped San Francisco four times on fourth down conversion attempts. Kyler Murray passed for 239 yards and a TD. 

Arizona head coach Kliff Kingsbury tested positive for COVID-19 and will not be on the sideline for Sunday’s game. Quarterbacks coach Cam Turner and defensive lineman Zach Allen also tested positive and will miss the game vs, Cleveland. Defensive coordinator Vance Joseph and special teams coordinator Jeff Rodgers are expected to share head coaching duties. The status of Chandler Jones, who tested positive earlier this week, is uncertain. 

How to make Cardinals vs. Browns picks

The model has simulated Browns vs. Cardinals 10,000 times and the results are in. It is leaning under on the total, and it’s also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Browns vs. Cardinals? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.

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