49ers vs. Saints prediction, odds, spread, line: 2022 NFL picks, Week 12 best bets from proven computer model

Andy Dalton and the New Orleans Saints (4-7) head to the West Coast to take on Jimmy Garoppolo and the red-hot San Francisco 49ers (6-4) on Sunday afternoon at Levi’s Stadium. The Saints are coming off a 27-20 win over the defending Super Bowl champion Los Angeles Rams, while the 49ers are looking to win their fourth straight after blowing out the Arizona Cardinals 38-10 on Monday Night Football in Mexico City. New Orleans is 4-7 against the spread, while San Francisco is 5-5 ATS in 2022.

Kickoff is at 4:25 p.m. ET. San Francisco is favored by 9 points in the latest 49ers vs. Saints odds from Caesars Sportsbook, and the over/under is set at 43.5. Before entering any Saints vs. 49ers picks, you need to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on 49ers vs. Saints and just locked in its picks and NFL Week 12 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Saints vs. 49ers:

  • 49ers vs. Saints spread: 49ers -9
  • 49ers vs. Saints over/under: 43.5 points
  • 49ers vs. Saints money line: San Francisco -440, New Orleans +335
  • 49ers vs. Saints picks: See picks here

Featured Game | San Francisco 49ers vs. New Orleans Saints

What you need to know about the 49ers

The 49ers were dominant in their 38-10 win over the Cardinals on Monday Night Football. Quarterback Jimmy Garoppolo completed 20 of 29 passes for 229 yards and four touchdowns. All-Pro tight end George Kittle hauled in four passes for 84 yards and two TDs, while wide receiver Brandon Aiyuk caught two passes for 20 yards with both going for touchdowns.

Since acquiring Christian McCaffrey, the 49ers have gone 3-1 and now look like a legitimate threat to represent the NFC in Super Bowl LVII. San Francisco was widely regarded as the league’s best defensive team, and now Garoppolo has arguably the NFL’s best arsenal of weapons at his disposal in McCaffrey, Kittle, Aiyuk, Elijah Mitchell, and Deebo Samuel.

What you need to know about the Saints

Meanwhile, New Orleans secured a 27-20 victory over the Los Angeles Rams this past Sunday. Dalton passed for three TDs and 260 yards on 25 attempts. Dalton’s 53-yard touchdown toss up the middle to WR Chris Olave in the third quarter made for one of the most memorable moments of the afternoon.

The Saints could get a much-needed boost this week with cornerback Marshon Lattimore (abdomen), cornerback Bradley Roby, defensive end Cameron Jordan (eye), defensive end Marcus Davenport (calf), left guard Andrus Peat (triceps), left tackle James Hurst (concussion) and running back Mark Ingram (knee) all returning to practice this week. They are all listed as questionable, with several expected to play on Sunday.

How to make 49ers vs. Saints picks

The model has simulated Saints vs. 49ers 10,000 times and the results are in. The model is leaning Over on the point total, and it’s also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the model’s pick at SportsLine.

So who wins Saints vs. 49ers? And which side of the spread hits well over 50% of the time? Visit SportsLine right now to find out which side of the 49ers vs. Saints spread you should be all over, all from the model on a 155-109 roll on its top-rated NFL picks, and find out.

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