2022 MLB odds, picks, predictions for Wednesday, May 18 from proven model: This four-way parlay pays 15-1

Logan Webb goes for his major-league leading sixth win of the season on Wednesday when he takes the mound for the San Francisco Giants against the Colorado Rockies at Coors Field in Denver. Webb (5-1, 3.48 ERA) is tied with the AstrosJustin Verlander for most wins this season. On Wednesday, Webb squares off against Kyle Freeland (1-4, 4.91). San Francisco is a -160 money-line favorite in the latest Giants vs. Rockies odds from Caesars Sportsbook, while Colorado is a +140 underdog. 

First pitch is set for 3:10 p.m. ET. The game is one of 15 on the MLB schedule on Wednesday. Elsewhere in the majors, Angels two-way star and reigning AL MVP Shohei Ohtani takes the mound against the Rangers, and Mets ace and St. Louis-area native Max Scherzer faces his hometown Cardinals. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and is off to a sizzling start to the 2022 season. It’s on a 33-25 roll on top-rated MLB money-line picks through six weeks, returning over $300 for $100 players. Anyone following it has seen some huge returns.

Now, the model has locked in four confident MLB best bets for Wednesday. All the games occur at 6:10 p.m. ET or later, so there’s still plenty of time to make these MLB picks. If you successfully parlay the picks, you’d be looking at a payout of 15-1. You can only see the model’s MLB picks at SportsLine.

Top MLB picks today

The model, which simulated every game on Wednesday’s schedule 10,000 times, is high on the Cleveland Guardians (-135) to beat the Cincinnati Reds at 6:10 p.m. ET (see tickets at StubHub). Cleveland (16-18) enters Wednesday’s game in third place in the AL Central, 3.5 games behind the division-leading Twins. Meanwhile, Cincinnati (10-26) owns the worst record in the majors.

Jose Ramirez has started the season off strongly for the Guardians. The three-time Silver Slugger leads the majors in RBI (33) and ranks ninth in OPS (.943). He also leads the team in home runs (eight), on-base percentage (.380) and hits (36). In eight at-bats against Tyler Mahle, who is slated to get the start for the Reds, Ramirez is batting .375 with a homer and four RBI.

Featured Game | Cleveland Guardians vs. Cincinnati Reds

How to make MLB picks and parlays for Wednesday

The model also locked in three other best bets for Wednesday, including a must-see play an an underdog that wins outright over 50 percent of the time. You can see the model’s MLB best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of 15-1? And what underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 33-25 roll on top-rated MLB money-line picks through six weeks.

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